Generalized Pustular Psoriasis and Hepatic Dysfunction Associated with Oral Terbinafine Therapy

Generalized Pustular Psoriasis and Hepatic Dysfunction Associated with Oral Terbinafine Therapy

We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's con...

Severe Generalized Pustular Psoriasis Provoked by Oral Terbinafine

Terbinafine is an allylamine antifungal agent. Its severe cutaneous adverse effects are rare, but toxic epidermal necrolysis, pustular drug eruption, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and erythema multiforme had been reported. Terbinafine was also reported to induce flare-up of chronic psoriasis or development of pustular psoriasis. Here we report a psoriatic...

Generalized pustular psoriasis of pregnancy treated with oral cyclosporin.

Infliximab in recalcitrant generalized pustular arthropatic psoriasis.

Generalized pustular psoriasis is an unstable inflammatory type of psoriasis, with widespread areas of erythema and sterile pustules, associated with fever and systemic symptoms. Infliximab is a monoclonal antibody with anti-TNFalpha activity, approved for use in psoriasis. We describe a male patient with a long history of stable arthropathic psoriasis, hospitalized with a generalized pustular ...

Acute generalized pustular psoriasis presenting with erythroderma associated with shock and acute renal failure.

Acute generalized pustular psoriasis is an uncommon but dangerous form of psoriasis with a systemic presentation. Acute exacerbation, an early picture of acute generalized pustular psoriasis (AGPP), can be fatal, therefore, early recognition and systemic therapy is critical. It is an important differential diagnosis of erythroderma. Epidemiology, etiology, diagnosis, and treatment options are d...